Welcome to the Marty Lab

Research in the Marty Lab is centered on characterization of membrane proteins and antimicrobial peptides by mass spectrometry. Our lab works at the interface of chemistry and biochemistry, combining cutting-edge analytical methodologies with biotechnology.

News

New Article in Analytical Chemistry

Congratulations to Julia, James, and our collaborators in the Prell lab for their new article in Analytical Chemistry on using novel charge reducing reagents to improve the stability of complexes for native MS.

Townsend, J.A.Keener, J.E.; Miller, Z.; Prell, J.S.; Marty, M.T. "Imidazole Derivatives Improve Charge Reduction and Stabilization for Native Mass Spectrometry." Anal. Chem. 2019, DOI: 10.1021/acs.analchem.1029b04263.

Prof. Marty on NPR

Prof. Marty sat down with Arizona Public Media to discuss their new work with antimicrobial peptides with Prof. Leslie Tolbert. Listen to the interview here: https://radio.azpm.org/p/radio-azscience/2019/8/23/157065-episode-196-molecules-and-the-battle-against-bacteria/

National Science Foundation CAREER Award

Congratulations to Prof. Marty on receiving an NSF CAREER award! This will fund new work in the lab on using native MS to study interactions of membrane active compounds such as antimicrobial peptides with lipid nanodiscs. It also supports ongoing development of UniDec. New tutorials for UniDec will be coming soon. Finally, it also supports development of the ASEMS-V program to engage Veterans in STEM Research in collaboration with the University of Arizona ASEMS program and the VETS center. Stay tuned...

New Article in Analytical Chemistry

Congrats to Larry, Elaine, Julia, and Will on their new article in Analytical Chemistry on using native MS to study antimicrobial peptide complex formation and lipid interactions in nanodiscs. It launches a new direction in the Marty lab on studying antimicrobial peptides in intact nanodiscs by native MS. 

Walker, L.R.; Marzluff, E.M.; Townsend, J.A.; Resager, W.C.; Marty, M.T. "Native Mass Spectrometry of Antimicrobial Peptides in Lipid Nanodiscs Elucidates Complex Assembly." Anal. Chem. 2019, ​​​​​​DOI: 10.1021/acs.analchem.1029b02261.

New Article in the Journal of the American Society for Mass Spectrometry

Congrats to Marius, Alex, Deseree and Jibriel on their new article in JASMS. This work focuses on native MS analysis of nanodiscs with a wider range of lipids, including glycolipid GM1, cardiolipin, and sterols. It also include our first results with Saposin A nanoparticles. Great work!

Kostelic, M.M.; Ryan, A.M.; Reid, D.J.; Noun, J.M.; Marty, M.T. Expanding the Types of Lipids Amenable to Native Mass Spectrometry of Lipoprotein Complexes. J. Am. Soc. Mass Spectrom. 2019, DOI: 10.1007/s13361-019-02174-x.

Native MS of nanodiscs with mixed lipids

New Article in the Journal of the American Chemical Society

Congrats to James, Dane, Guozhi, Ciara, and Deseree on the publication of their paper in JACS! This work demonstrated the first native MS measurement of membrane protein oligomeric state within a lipid bilayer environment. Deseree did an awesome job sketching the concept below. Thanks also to collaborators in the Pemberton and Prell labs. Well done team!

Keener, J.E.Zambrano, D.E.Zhang, G.Zak, C.K.Reid, D.J.; Deodhar, B.S.; Pemberton, J.E.; Prell, J.S.; Marty, M.T. Chemical additives enable native mass spectrometry measurement of membrane protein oligomeric state within intact nanodiscs. J. Am. Chem. Soc. 2019, 141, 1054-1061.

Nanodisc supercharging

National Institutes of Health MIRA Award

Congratulations to Prof. Marty on being awarded the National Institutes of Health/National Institute of General Medical Sciences Maximizing Investigator's Research Award (MIRA) R35 GM128624! This grant will support the lab efforts to employ native mass spectrometry and nanodiscs to understanding membrane protein-lipid interactions.

Congrats to Dane and Jessica on Graduating

Congratulations to Dane Zambrano and Jessica Diesing on their graduation and successful completion of their undergraduate theses. Jessica was also recently awarded the CBC Outstanding Peer Mentor Award and CBC Student of the Month. Congrats!

American Society for Mass Spectrometry Research Award

Congratulations to Prof. Marty on being awarded one of the 2018 ASMS Research Awards! Thanks to Thermo Fisher for sponsoring the award.

New Article in Journal of the American Society for Mass Spectrometry

Check out our new article on MetaUniDec, software for high throughput deconvolution of native mass spectra:

Reid, D. J.; Diesing, J. M.; Miller, M. A.; Perry, S. M.; Wales, J. A.; Montfort, W. R.; Marty, M. T. MetaUniDec: High-Throughput Deconvolution of Native Mass Spectra. J. Am. Soc. Mass. Spectrom. 2018, DOI: 10.1007/s13361-13018-11951-13369.

The software can be downloaded from links in the software tab. Happy deconvolving!

Congrats to Dane Zambrano

Undergrad, Dane Zambrano, has been with the Marty Lab since Day 1. She is graduating soon and has garnered some of the top awards from the CBC department, including the Excellence in Undergraduate Research Award. Congrats to Dane and good luck in grad school at UW Seattle!

https://cbc.arizona.edu/spotlight/dane-zambrano-wins-cbc-excellence-undergraduate-research-award

New Article in Analytical Chemistry

Check out our new article describing engineering of nanodiscs for native mass spectrometry.

Reid, D.J.; Keener, J.E.; Wheeler, A.P.; Zambrano, D.E.; Diesing, J.M.; Reinhardt-Szyba, M.; Makarov, A.A.; Marty, M.T. "Engineering Nanodisc Scaffold Proteins for Native Mass SpectrometryAnal. Chem. 2017, DOI: 10.1021/acs.analchem.7b03569

Plasmids used in this study can be acquired from Addgene: http://www.addgene.org/Michael_Marty/

Bisgrove Scholar Award

Congratulations to Prof. Marty on being awarded the Bisgrove Scholar Award from Science Foundation Arizona. For more information, take a look at this article.

SFAZ Logo

New Review Article

A review of membrane mimetics for mass spectrometry was recently published in Accounts of Chemical Research. For those interested in learning more about our research, this is a great place to start.

Marty, M.T.; Hoi, K.K.; Robinson, C.V. "Interfacing Membrane Mimetics with Mass Spectrometry" Acc. Chem. Res. 2016, DOI: 10.1021/acs.accounts.6b00379