The Marty Lab
Shepard, A.J.; Townsend, J.A.; Foley, C.; Hulme, C.; Marty, M.T.; Jewett, J.C. “Suzuki Coupling of Protected Aryl Diazonium Ions: Expanding the Knowledge of Triazabutadiene Compatible Reactions” Org. Lett. 2021, DOI: 10.1021/acs.orglett.1021c00257.
Wijetunge, A.N.; Davis, G.J.; Shadmehr, M.; Townsend, J.A.; Marty, M.T.; Jewett, J.C. “Copper-free click enabled triazabutadiene for biorthogonal protein functionalization” Bioconjug. Chem. 2021, DOI: 10.1021/acs.bioconjchem.1020c00677.
Marty, M.T. "Illuminating Individual Membrane Protein Complexes with Mass Photometry." Chem 2020, DOI: 10.1016/j.chempr.2020.1012.1012.
Harvey, S.R.; Van Aernum, Z.L.; Kostelic, M.M.; Marty, M.T.; Wysocki, V.H. “Probing the structures of nanodiscs using surfaced-induced dissociation mass spectrometry” Chem. Comm. 2020. DOI: 10.1039/D0CC05531J
Norris, C.; Keener, J.E.; Perera, S.M.D.C.; Weerasinghe, N.; Fried, S.D.E.; Resager, W.C.; Rohrbough, J.G.; Brown, M.F.; Marty, M.T. “Native Mass Spectrometry Reveals the Simultaneous Binding of Lipids and Zinc to Rhodopsin” Int. J. Mass Spectrom. 2020. DOI: 10.1016/j.ijms.2020.116477.
Sacco, M.D.; Ma, C.; Lagarias, P.; Gao, A.; Townsend, J.A.; Meng, X.; Dube, P.; Zhang, X.; Hu, Y.; Kitamura, N.; Hurst, B.; Tarbet, B.; Marty. M.T.; Kolocouris, A.; Xiang, Y.; Chen, Y.; Wang, J. “Structure and inhibition of the SARS-CoV-2 main protease reveals strategy for developing dual inhibitors against Mpro and cathepsin L”. Sci. Adv. 2020. 6, eabe0751.
Keener, J.E.; Zhang, G.; Marty, M.T. “Native Mass Spectrometry of Membrane Proteins” Anal. Chem. 2020. DOI: 10.1021/acs.analchem.0c04342.
Ma, C.; Hu, Y.; Townsend, J.A.; Lagarias, P.I.; Marty, M.T.; Kolocouris, A.; Wang, J. “Ebselen, Disulfiram, Carmofur, PX-12, Tideglusib, and Shikonin Are Nonspecific Promiscuous SARS-CoV-2 Main Protease Inhibitors”. ACS Pharmacol. Transl. Sci. 2020. DOI: 10.1021/acsptsci.1020c00130.
Marty, M.T. “Nanodiscs and Mass Spectrometry: Making Membranes Fly” Int. J. Mass Spectrom. 2020, 458, 116436.
Tan, Y.Z.; Rodrigues, J.; Keener, J.E.; Zheng, R.B.; Brunton, R.; Kloss, B.; Giacometti, S.I.; Rosario, A.L.; Zhang, L.; Niederweis, M.; Clarke, O.B.; Lowary, T.L.; Marty, M.T.; Archer, M.; Potter, C.S.; Carragher, B.; Mancia, F. “Cryo-EM Structure of Arabinosyltransferase EmbB from Mycobacterium smegmatis” Nature Commun. 2020, 11, 3396.
Ma, C.; Sacco, M.D.; Hurst, B.; Townsend, J.A.; Hu, Y.; Szeto, T.; Zhang, X.; Tarbet, B.; Marty, M.T.; Chen, Yu; Wang, J. “Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease” Cell Research. 2020, 30, 678-692.
Walker, L.R.; Marty, M.T. “Revealing the Specificity of a Range of Antimicrobial Peptides in Lipid Nanodiscs by Native Mass Spectrometry” Biochemistry. 2020, 59, 2135-2142.
Zhang, G.; Keener, J.E.; Marty, M.T. “Measuring Remodeling of the Lipid Environment Surrounding Membrane Proteins with Lipid Exchange and Native Mass Spectrometry.” Anal. Chem. 2020, 92, 5666-5669.
Marty, M.T. “A Universal Score for Deconvolution of Intact Protein and Native Electrospray Mass Spectra.” Anal. Chem. 2020, 92, 4395-4401.
Sahin, C.; Reid, D.J.; Marty, M.T.; Landreh, M. “Scratching the surface: Native mass spectrometry of peripheral membrane protein complexes.” Biochem. Soc. Trans. 2020, 48, 547-558.
Townsend, J.A.; Keener, J.E.; Miller, Z.; Prell, J.S.; Marty, M.T. "Imidazole Derivatives Improve Charge Reduction and Stabilization for Native Mass Spectrometry." Anal. Chem. 2019, 91, 14765-14772.
Marty. M.T. “Eliminating Artifacts in Electrospray Deconvolution with a SoftMax Function.” J. Am. Soc. Mass Spectrom. 2019, 30, 2174-2177.
Walker, L.R.; Marzluff, E.M.; Townsend, J.A.; Resager, W.C.; Marty, M.T. "Native Mass Spectrometry of Antimicrobial Peptides in Lipid Nanodiscs Elucidates Complex Assembly." Anal. Chem. 2019, 91, 9284-9291.
Kostelic, M.M.; Ryan, A.M.; Reid, D.J.; Noun, J.M.; Marty, M.T. Expanding the Types of Lipids Amenable to Native Mass Spectrometry of Lipoprotein Complexes. J. Am. Soc. Mass Spectrom. 2019, 30, 1416-1425.
Musharrafieh, R.; Ma, C; Zhang, J.; Hu, Y.; Diesing, J. M.; Marty, M. T.; Wang J. Validating Enterovirus D68-2Apro as an Antiviral Drug Target and the Discovery of Telaprevir as a potent D68-2Apro Inhibitor. J. Virology. 2019, 93, JVI.02221-02218.
Keener, J.E.; Zambrano, D.E.; Zhang, G.; Zak, C.K.; Reid, D.J.; Deodhar, B.S.; Pemberton, J.E.; Prell, J.S.; Marty, M.T. Chemical additives enable native mass spectrometry measurement of membrane protein oligomeric state within intact nanodiscs. J. Am. Chem. Soc. 2019, 141. 1054-1061.
Reid, D. J.; Diesing, J. M.; Miller, M. A.; Perry, S. M.; Wales, J. A.; Montfort, W. R.; Marty, M. T. MetaUniDec: High-Throughput Deconvolution of Native Mass Spectra. J. Am. Soc. Mass. Spectrom. 2019, 30, 118-127.
Lippins, J.L.; Egea, P.F.; Spahr, C.; Vaish, A.; Keener, J.E.; Marty, M.T.; Loo, J.A.; Campuzano, I.D.G. A Rapid LC-MS Method for Accurate Molecular Weight Determination of Membrane and Hydrophobic Proteins. Anal. Chem. 2018, 90, 13616-13623.
Reid, D.J.; Keener, J.E.; Wheeler, A.P.; Zambrano, D.E.; Diesing, J.M.; Reinhardt-Szyba, M.; Makarov, A.A.; Marty, M.T. "Engineering Nanodisc Scaffold Proteins for Native Mass Spectrometry" Anal. Chem. 2017, 89, 11189-11192.
Moutal, A.; Wang, Y.; Yang, X.; Ji, Y.; Luo, S.; Dorame, A.; Bellampalli, S. S.; Chew, L. A.; Cai, S.; Dustrude, E. T.; Keener, J. E.; Marty, M. T.; Vanderah, T. W.; Khanna, R. "Dissecting the role of the CRMP2-neurofibromin complex on pain behaviors" Pain 2017. 158, 2203-2221.
Marty, M.T.; Hoi, K.K.; Robinson, C.V. "Interfacing Membrane Mimetics with Mass Spectrometry" Acc. Chem. Res. 2016, 49, 2459–2467.
Prior Work
Hochberg, G. K. A.; Shepherd, D. A.; Marklund, E. G.; Santhanagoplan, I.; Degiacomi, M. T.; Laganowsky, A.; Allison, T. M.; Basha, E.; Marty, M. T.; Galpin, M. R.; Struwe, W. B.; Baldwin, A. J.; Vierling, E.; Benesch, J. L. P. Structural principles that enable oligomeric small heat-shock protein paralogs to evolve distinct functions. Science 2018, 359, 930.
Hoi, K.K.; Robinson, C.V.; Marty, M.T. “Unraveling the Composition and Behavior of Heterogeneous Lipid Nanodiscs by Mass Spectrometry” Anal. Chem. 2016, 88, 6199-6204.
Landreh, M.; Marty, M.T.; Gault, J.; Robinson, C.V. “A sliding selectivity scale for lipid binding to membrane proteins” Curr. Opin. Struct. Biol. 2016, 39, 54-60.
Gault, J.; Donlan, J. A.C.; Liko, I.; Hopper, J.T.S.; Gupta, K.; Housden, N.G.; Struwe, W.B.; Marty, M.T.; Mize, T.; Bechara, C.; Zhu, Y.; Wu, B.; Kleanthous, C.; Belov, M.; Damoc, E.; Makarov, A.; Robinson, C.V. “High-resolution mass spectrometry of small molecules bound to membrane proteins” Nat. Meth. 2016, 13, 333-336.
Marty, M.T.; Hoi, K.K.; Gault, J.; Robinson, C.V. “Probing the Lipid Annular Belt by Gas-phase Dissociation of Membrane Proteins in Nanodiscs” Angew. Chemie. Int. Ed. 2016, 55, 550-554.
Reading, E.; Walton, T.A.; Liko, I.; Marty, M.T.; Laganowsky, A.; Rees, D.C.; Robinson, C.V. “The Effect of Detergent, Temperature, and Lipid on the Oligomeric State of MscL Constructs: Insights from Mass Spectrometry” Chem. Biol. 2015, 22, 593-603.
Wilcox, K.C.; Marunde, M.; Das, A.; Velasco, P.T.; Kuhns, B.; Marty, M.T.; Jiang, H.; Lacor, P.; Luan, C.-H.; Sligar, S.G.; Klein, W.L. “Nanoscale Synaptic Membrane Mimetic Allows Unbiased High Throughput Screen that Targets Binding Sites for Alzheimer's-associated Aβ Oligomers” PLoS One. 2015, DOI: 10.1371/journal.pone.0125263
Marty, M.T.; Baldwin A.J.; Marklund, E.G.; Hochberg, G.K.A.; Benesch, J.L.P.; Robinson C.V. “Bayesian Deconvolution of Mass and Ion Mobility Spectra: From Binary Interactions to Polydisperse Ensembles” Anal. Chem. 2015, 87, 4370-4376.
Shepherd, D.A.; Marty, M.T.; Giles, K; Baldwin, A.J.; Benesch J.L.P. “Combining Tandem Mass Spectrometry with Ion Mobility Separation to Determine the Architecture of Polydisperse Proteins” Int. J. Mass Spectrom. 2015, 377, 663-671.
Marty, M.T.; Zhang, H.; Cui, W.; Gross, M.L.; Sligar, S.G. “Interpretation and Deconvolution of Nanodisc Native Mass Spectra” J. Am. Soc. Mass Spectrom. 2014, 25, 269-277.
Sloan, C.D.K.; Marty, M.T.; Sligar, S.G.; Bailey, R.C. “Investigating Lipid-Protein and Protein-Protein Interactions via Nanodiscs Immobilized on Silicon Photonic Sensor Arrays” Anal. Chem. 2013, 85, 2970-2976.
Marty, M.T.; Wilcox, K.C.; Klein, W.L.; Sligar, S.G. “Nanodisc-Solubilized Membrane Protein Library Reflects the Membrane Proteome” Anal. Bioanal. Chem. 2013, 405, 4009-4016.
Marty, M.T.; Beussman, D.J. “Simulating a Time-of-Flight Mass Spectrometer: A LabView® Exercise” J. Chem. Ed. 2013, 90, 239-243.
Marty, M.T.; Zhang, H.; Cui, W.; Blankenship, R.E.; Gross, M.L.; Sligar, S.G. “Native Mass Spectrometry Characterization of Intact Nanodisc Lipoprotein Complexes” Anal Chem. 2012, 84, 8957-8960.
Marty, M.T.; Sloan, C.D.K.; Bailey, R.C.; Sligar, S.G. “Nonlinear Analyte Concentration Gradients for One-Step Kinetic Analysis Employing Optical Microring Resonators” Anal. Chem. 2012, 84, 5556-5564.
Marty, M.T.; Das, A.; Sligar, S.G. “Ultra-thin Layer MALDI Mass Spectrometry of Membrane Proteins in Nanodiscs” Anal. Bioanal. Chem. 2012, 402, 721-729.